Monterrey have an important lead on the standings with four rounds of games left.
America will use their home advantage to try to close the ten-point gap between them and their rivals, despite their desire to maintain their lead.
Aguilas are fourth with 24 places - one point behind second and third-put Toluca and Leon.
Without participating in the reclassification, the top four teams advance to the Clausura final phase quarterfinals.
The last time Monterrey won the title was in 2003, and they are on track to do so again.
With 11 wins, one draw, and a loss in 13 games, they are having an excellent campaign.
They have won ten of their 11 games, going unbeaten. Monterrey beat America 3-2 when the different sides last met.
After a staggering 4-0 victory over Tijuana, Rayados enters the match.